Osteoporosis and Ostobolan®
Osteoporosis. What is it?
The name of the disease originates in three Greek words:
- osteon - bone
- poros - pore
- osis - hole (osteoporosis)
As one can see by the name, the illness arises in the bones, specifically in the inner structure of a bone.
The bones, together with the cartilaginous tissue, make a skeletal system. The osteal tissue is responsible for three major functions in our body:
- Mechanical
- Protective
- Metabolic (participation in metabolism of our organism).
Mechanical function: bones, cartilages and muscles make a locomotion system; the strength of the bones is an indispensable condition of this function.
Protective function: the bones construct a skeleton (framework) for the vital organs of the body. The bones also are a receptacle for the bone marrow, this is where the blood cells and the immune system come from.
Metabolic function: the osteal tissue is where the depot of calcium and phosphorus takes place in our body, playing the relevant role in maintenance of the internal structure of body as a whole.
The human skeleton is not only a supportive body, but also a great reserve of minerals, a major organ of mineral metabolism and in particular the exchange of calcium. The stable level of calcium provides such vital functions as: conduction of nerve impulses, muscular contraction, coagulation of blood, enzymatic processes.
The “osteal girders” which provide strength of a bone and its weight represent the basis of the internal structure of a bone. Between osteal girders there are osteal cells. During life these osteal girders are continuously renewed.
Osteoporosis is a disease of the bones characterized by a decrease of osteal density and disturbance of microarchetonics of the osteal tissue. The number of osteal girders decreases, and the osteal cells grow in their size. The outer appearance of a bone thus remains unchanged. Osteoporotic bones look absolutely healthy from the outside, but inside osteal girders are replaced by cavities and as a result a bone becomes fragile. The osteal system becomes easily vulnerable and cannot adequately resist even ordinary physiological loads. The bones steadily growing brittleness results in increasing risk of fractures, which is the most significant clinical aspect of the disease.
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Bone
without Osteoporosis |
Bone
with Osteoporosis |
Osteoporosis. Reasons.
Until recently osteoporosis was not considered as a disease, but was considered as an unavoidable companion of aging. Now around the world specialists consider osteoporosis as a progressing general disease marked with a decrease of osteal tissue density and the disturbance of its micro architectonics along with a constant increase of brittleness of the bones and an increasing risk the fractures.
Bones of a healthy person grow until around 30 years of age. Then the gradual and natural decrease of osteal tissue weight and its strength starts.
A huge role in the development of osteoporosis is played by our endocrine system. Hormones developed by endocrine glands, among others, control the de oxidation process of osteal tissues. Therefore women are subject to osteoporosis more often than men and at younger ages. The problem is that with the approach of menopause, the hormonal changes of the whole female body starts. The ovaries, step-by-step, cease to produce sexual hormones called estrogens, which play a very important role in absorption of calcium and vitamin D3 in the bones. Low bone mineral density and increased of loss of osteal weight during menopause, are the main risk factors in the development of osteoporosis.
The deficit of sexual hormones, both for women and for men, is a very important reason for the development of osteoporosis.
With age the absorption of calcium in the intestines decreases, along with vitamin D3. This insufficiency leads to a higher secretion of parathormone (hormone of the parathyroid glands) and the bones loose valuable calcium.
The lack of exercise also promotes the loss of osteal tissue.
Different diseases can contribute to the onset of osteoporosis too: long pre-menopause amenorrhea, ovariectomy, early menopause, hyperparathyroidism, hyperthyroidism, mal absorption syndrome, chronic diseases of liver and nephroses, long-term immobilization and acceptance of steroids all can cause the onset of osteoporosis.
Osteoporosis. Clinical signs of illness.
Osteoporosis is a slowly developing disease with long-term latency. Clinically it has been observed that pain syndromes accompany any fracture.
The majority of people don’t even suspect they are suffering from osteoporosis and generally will not find out until an X-ray examination reveals the osteal changes (demineralization), decrease in height of the vertebrae or their wedge-shaped deformation.
Alarming signs of possible osteoporosis might be:
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- casual pains in the back due to ordinary physiological load activity or for example by lifting weights
- fatigability and intense pain in the back after a prolonged stay in one position or by walking.
Very often patients with chronic back pain are send from a therapist to a neuropathologist and finally to a surgeon, with the diagnosis of "spondylosis" or "osteochondrosis" and is not adequately treated.
As already mentioned, osteoporosis is very difficult to diagnose in the early stages of the disease. In 90% of cases, osteoporosis is discovered by the patient for the first time only after a fracture has happened and when more than 35% of osteal weight has already been lost.
Fractures are typical with osteoporosis, with fractures of the femur neck, spine and forearm the most common. Often the slightest trauma can cause a fracture. The elderly, especially after 60, with osteoporosis will commonly suffer from a fracture of the femur neck caused by a simple fall.
Acute pain in the chest or stomach area is often the first sign of a compression fracture of vertebrae. Sometimes the first signs of compression fractures of the vertebrae resembles a clinical example of a myocardial infraction or aperitifs. More often the compression of vertebrae happens step-by-step and is accompanied by constant but moderate and strengthening pain in thoracal area of the spinal column. With time, it results in a decrease of the patient's height (sometimes up to 10-15 cm), deformation of the spinal column in the thoracal area and is commonly referred to as "widow's humpback".
The constant pain in the spinal column or in the thoracal area can result in neurological disorders and lead to depression.
Osteoporosis. The risk factors of disease development.
The origin and development of osteoporosis can be explained by the effect of many different factors stemming from both the environment and from your own body, but the effect of some of them is not fully understood or proven yet.
Low mineral density of the bones and increased loss of osteal weight in menopause (according to densitometry) are factors of risk contributing to the development of osteoporosis. There are also other additional risk factors to the development of Osteoporotic fractures:
- Age
- Early natural or surgical menopause (removing or partial removing of considerable part of ovaries)
- Low levels of sexual hormones (estrogens, Testosterone)
- Genetic predisposition
- Low body weight or height
- Decreased physical activity
- Low levels of vitamin D
- Low calcium nutrition
- Consumption of drugs (corticosteroids, anticonvulsive).
Other important factors are the gynecological anamnesis of a woman: childbirth, feeding of a baby, delayed menstrual function, disturbance of the menstrual cycle.
Coffee, smoking, alcohol.
The majority of medical scientists consider that the exuberant consumption of coffee results in a decreased calcium content in our system because calcium exits our body with urine and accordingly brings us closer to osteoporosis. However there are no final proofs of this effect.
But it is clinically observed and proven that if a person drinks coffee with milk, bone density is not affected as much as opposed to drinking coffee without milk.
The undesirable effects of smoking on osteal weight is probably caused by changes in estrogen exchange as a result of a decrease in the production of estrogens. There are opinions that low body weight in the bodies of women that smoke and also directly, or indirectly, the influence of nicotine on osteal restoration, is one of the reasons for a negative effect on osteal weight due to smoking. Also it is proven that smoking is a predisposing factor for early menopause.
Alcohol consumption in people suffering from osteoporosis might be caused by constant disturbance of absorption and digestion in the intestines. Alcohol also affects the level of hormones regulating osteal metabolism.
Osteoporosis. Different kinds.
Osteoporosis is subdivided into primary and secondary.
Primary osteoporosis is a complex, multifaceted phenomenon. Doubtlessly, the important role in this case is contributed by genetic and racial influences of osteal weight, which is usually built up to its maximum by time one is 30, and physical activity positively effects the initial osteal weight and contributes to a slowdown of caries.
Factors such as larger or smaller boned persons have different effects on estrogen deficiencies, specially for women after menopause. Diets poor in calcium and rich in protein, called Phytinum nutrition, causes hormonal disturbances in the body which in turn causes a poor blood supply to the bone marrow.
The primary osteoporosis happens even to very young people of 11-15 years of age (called "juvenile osteoporosis") during their puberty; or in other forms like "idiopathic osteoporosis" which strikes men and women at the age of between 20 and 50 years, for women pregnancy and breast feeding being often a starting factor.
"Postmenopausal osteoporosis" is observed in 25 - 30% of women after 51 years of age. Genetic and environmental (bad nutrition, low exercise, unhealthy habits) factors play a significant role in this case, too.
"Senile osteoporosis" is more frequent in women after 70 (note, women suffer Senile osteoporosis twice as often as men do).
Secondary osteoporosis. arises as a sign of other diseases or after their treatment. The reasons of secondary osteoporosis can be as follows:
Hormonally caused secondary osteoporosis. Arises from diseases of the endocrine organs, such as Cushing syndrome, hyperthyroidism, hyperparathyroidism and also in long-term treatment of different diseases with application steroid hormones. The osteoporosis is observed also as complication of sugar diabetes.
Osteoporosis caused by gastrointestinal diseases. The different gastrointestinal diseases can stimulate diminished absorption of calcium and phosphorus often combined to disturbance of exchange of the vitamin D and a deficit of proteins in our body. Often outcome of these complex disturbances is osteoporosis.
Osteoporosis caused by neuralgic diseases. Arises more often during puberty of girls and is characterized by loss of appetite and considerable decrease of a body weight.
Osteoporosis caused by disturbance of nutrition. The limited consumption of calcium-rich food is one of the main reasons of development of osteoporosis. The achievement of normal osteal weight for the adolescents depends on quantity of calcium consumed with nutrition. The sufficient consumption of calcium remains relevant during pregnancy, lactemia, when the requirement for calcium considerably increases. A deficit in food calcium is one of the relevant reasons for postmenopausal osteoporosis to develop. The increase of consumption of phosphorus with nutrition also can result in osteoporosis. The excessive consumption by youth of drinks like Coca-Cola augments consumption of phosphorus and contributes to disturbance in osteogenesis.
Osteoporosis caused by Immobilization. Arises at long-term immobilization of a person. Decrease in blood supply of bones and muscles are the main reason for osteoporosis in this case. Young people in the most of the cases have quite promising prospects to recover their osteal tissues after a long-term immobilization but for the elderly and aged people the osteoporosis becomes quite often irreversible.
Osteoporosis due to long-term application of medications and drugs, specifically corticosteroids.
Osteoporosis. Diagnosis.
The main diagnostic method of osteoporosis is the X-ray of bones and osteodensitometry. In complex cases X-ray densitometry, computer tomography and X-ray morphometry are used too.
X-ray, used to diagnose osteoporosis, is less informative than other methods, as it allows to reveal osteoporosis at loss of 30-40% of osteal weight. In other words, X-ray inspection does not allow the precise diagnosis "osteoporosis" at early stages of illness. The given method legibly works only at the expressed osteoporosis and allows rather reliably to recognize osteoporosis and to evaluate its expressiveness in bones of upper and lower extremities (peripheral skeleton).
It is considerably more difficult to discover osteoporosis and to evaluate its degree in vertebrae and ribs with X-ray.
Based on the results of X-rays and depending of the severity of the disease there are 4 degrees of osteoporosis:
1 degree - suspicion of osteoporosis;
2 degree - mild osteoporosis;
3 degree - moderate osteoporosis;
4 degree - heavy osteoporosis.
X-ray morphometry. It is the qualitative analysis of X-rays by measurement of width of osteal tissue at defined locations of the bones of the upper and lower extremities and vertebrae.
Now there is an objective method for the quantitative evaluation of mineral density of bones and osteoporosis degree called osteodensitomerty. The most proliferated are x-ray (gamma), ultrasonic densitometry and quantitative computer tomography. The estimation technique of x-ray and ultrasound outcomes coincide in many respects.
The densitometry measures a standard density osteal weight compared to the mineral density of osteal tissue. The measurement of mineral density of osteal tissue is called "noninvasive" method of testing (i.e. without damage of dermal covers), is made within several minutes and can be repeated multiple times on the patient, without subjecting body to radiation load.
It is necessary to understand that any of methods used for the diagnosis of osteoporosis it will not reveal the cause of the disease. It is necessary to take densitometry measurements once a year for the recognition and identification of osteoporosis for all women after menopause and elderly men.
Osteoporosis. How to prevent it?
Some preventive actions are available to all of us without exception. Ideally, preventive maintenance should start in early childhood to assure an adequate supply of calcium with vitamin D to the body along with regular physical exercise for the maximum osteal weight possible.
The special value of daily supply of calcium with vitamin D gains after 30. Unfortunately the loss of osteal weight is renewed with the termination of acceptance of calcium and vitamins and all favorable effect of therapy on a bone is quickly lost. Therefore women in and after menopause and the elderly men should use Ostobolan® constantly.
To prevent development of osteoporosis or to slow it down it is necessary:
1. To eat food with the sufficient contents of calcium (1200-1500 mg/day): dairy products like yogurt, milk, cheese; fish and such vegetables as turnip, soy and cabbage.
2. Constantly consume high-calcium substances, e.g. Ostobolan®.
3. Vitamin D which is indispensable for healthy bones e.g. outdoor / sun in moderation.
4. Moderate exercising, e.g. walk 1-2 hours a day, gymnastics, bicycle, swimming.
5. Exclude negative influences.
Pregnancy, breast-feeding and a number of chronic diseases limiting the locomotion of a person are known as conditions boosting the need of an organism of salts in calcium. If a person is in a condition of enforced limitation of muscle performance, then different disorders of trophicity and mineral metabolism, including muscle atrophy, decalcification of bones, hyperlithiasis and clotting of veins arise. The preventive maintenance and treatment of osteoporosis is based on application of food supplements breaking the destruction of a bone or challenging its derivation. Your daily recommended dose of calcium consumption is 1000-1500 mg.
Osteoporosis. Treatment.
It is important to note, that patients with higher risk of fractures are treated first of all. Each sixth woman is subject to risk of a fracture of femoral bone and vertebrae during her life, and therefore the majority of the elderly women fall under this category.
Once started the therapy should be prolonged during the rest of life, except for cases of cancellation of steroids and normalization of osteal density.
As preventive measures it is necessary to exercise your body regularly including lifting weight, to receive calcium with vitamin D, to give up smoking and to limit consumption of alcohol. Calcium and vitamin D, being integral substances of Ostobolan® slow down the destruction of bones and reduce frequency of fractures in elderly age.
Thus the main therapy of osteoporosis should be conducted by food supplements influential directly in osteal metabolism and maintaining balance of calcium in your body. The therapy is carried out durably by the way of continuous course treatment.
Besides the diet with high concentration of calcium and phosphorus is recommended.
The very relevant factors in treatment of osteoporosis is your personal accountable attitude and believe in success of treatment, namely the systematic acceptance of Ostobolan® prescribed by your physician during indicated period of time and following the advised diet and way of life.
Fractures: preventing and treatment.
Risk of a fracture hereafter increases five times for those who already have had minor traumatic fractures. But this hazard can be avoided if you take preventive measures and treat low osteal weight, as described above.
OSTOBOLAN®, Doctor recommended and clinically tested
The basic task of Ostobolan® is to limit development of osteal destruction process and to prevent fractures of bones. Unfortunately, the global experience displays, that the pharmacotherapy of patients with osteoporosis does not result in increase of osteal weight and only limits caries, reducing losses of bone weight. When treated with Ostobolan® there are clinical estimations of reduction or complete disappearance of pains in bones, extension of motor performance and a significant improvement of the whole quality of life.
As it is known that one of the reasons of osteoporosis development is the reduction of calcium absorption in the intestine (the absorption is controlled by vitamin D3), therefore calcium in particular Calcium carbonate and vitamin D3 are included in Ostobolan® formula.
Usage of Calcium carbonate in Ostobolan® formula not only slows down the loss of bone weight but also reduces frequency of fractures of bones. A preventive role of calcium in fighting to stop osteoporosis development thus is reached. At the same time salts of calcium have no independent value in treatment of osteoporosis therefore in Ostobolan® Calcium carbonate is applied in a complex with other means of nosotropic (pathogenetic) therapy, in particularly with vitamin D3. This is due to the fact that high concentration of calcium in blood cannot provide its optimum contents in osteal tissues, which in turn is of a special importance to people with osteoporosis.
It's proved that Calcium carbonate and Vitamin D3 have to be consumed simultaneously to maintenance optimum level of calcium in the human blood.
Vitamin D3 and its fissile metabolites are components of a special system regulating phosphate-calcium exchange and participating in salinity of osteal tissues along with maintenance of datum level of calcium. Thus the fissile metabolites of vitamin D do not need to go through all phases of penetrating an organism to render the final effect. At course therapy they not only prevent further loss of osteal weight but also help bones to increase in weight and reduce risk of fractures, normalizing mineral metabolism.
Vitamin C plays the most important and vital role in habitability of our organism. It dramatically helps to reconstruct and rebuild almost all of the elements and parts of our whole body. Vitamin C participates in regulation of many processes; in particular it promotes recovery, including the human osteal system. It is interesting to note that a human body is not capable to synthesize vitamin C independently and the only way to supply our body with vitamin C is in form of nutrition.
Vitamin E is a natural antioxygenic substance (antioxidant). The vitamin E defends different matters in our body from oxidative changes. The participation of Vitamin E in Ostobolan® formula explains the positive influence of Ostobolan® on muscles, cardiac muscle and veins. Besides that Vitamin E actively participates in preventing disturbance of menstrual cycle and hinders disturbance of sexual glands' function with men. Such disturbance of menstrual cycle at women and problems with function of sexual glands at men, as indicated above, are the factors of high risk when osteoporosis develops.
The development of osteoporosis can be also stipulated by a deficit of trace elements. So the limited supply of Magnesium delays any derivation of calcium phosphate. Magnesium is one of the basic elements in a structure of enzymes indispensable for a metabolism in cartilages and connective tissues. Magnesium carbonate is one of the ingredients of Ostobolan® formula and prevents the extension of the medullar spaces and deformations of the skeleton.
The combined application of Vitamin C and Vitamin E with other ingredients in Ostobolan® formula allows rendering a positive effect not only directly at the osteal system, but also on the body as a whole. Ostobolan® supports the basic processes of metabolism in an organism.
Therefore Ostobolan® is recommended as preventive maintenance of osteoporosis for people over 30. Besides Ostobolan® is strongly recommended as an herbal supplement and maintaining substance for women and men with primary and secondary osteoporosis.
Two other main ingredients, which turn Ostobolan® into indispensable daily substance for the body, are Devil’s Claw (Harpagophytum procumbens) and Horsetail (Equisetum arvensis).
What you should know about Ostobolan®.
Doctor recommended and Clinically tested
It is made from 100 % natural substances, without preservatives or sugar
Has a positive effect not only on the osteal system, but the body
as a whole.
Terminates or eliminates loss of osteal tissue.
Boosts derivation of a new bone.
Increase strength of osteal tissue.
Reduces risks
of fractures.
Renders anesthetizing
operations at ostealgias.
Primary and
secondary prevention of Arthritis and Osteoporosis.
Supports the
bone metabolism.
Supplies calcium
and magnesium.
Reduces or eliminates
chronicle and general motion pain.
Recommended
for women during menopause.
It is well accepted
by your body.
Strong reduction
of cellulites.
No negative
side effects.
Recommended use: 3 times daily 2 capsules
The relevant factor
in treatment of osteoporosis is your personal attitude and belief in success
of treatment, namely the systematic acceptance of OSTOBOLAN®.
Prof. MD. Ph.D.
Oleg Dolnytsky
MD. D.Sc.Ph.D.
Trevor Carmichael
MD. Carlos Mejia